These could change your life. Seriously. .

Pro-resolving mediators (PRMs), sometimes called specialized pro-resolving mediators (SPMs), are a class of bioactive lipids that play a crucial role in resolving inflammation. They are produced from polyunsaturated fats (omega-6 and omega-3) and are involved in the active resolution of inflammation.

There are four main categories of PRMs:

1. Lipoxins: derived from arachidonic acid (omega-6 fat); involved in the resolution of inflammation and the promotion of tissue repair.
2. Resolvins: produced from the omega-3 fatty acids EPA and DHA; have been shown to reduce inflammation, promote tissue repair and improve cardiovascular health.
3. Protectins: derived from DHA; have anti-inflammatory and pro-resolving effects.
4. Maresins: derived from DHA and help stimulate tissue regeneration, especially with chronic inflammation.

PRMs have several key functions in the body:

1. Reducing inflammation by inhibiting the production of pro-inflammatory cytokines and promoting the migration of immune cells out of inflamed tissues.
2. Promoting tissue repair by enhancing the clearance of apoptotic cells, promoting tissue regeneration and improving wound healing.
3. Regulating immune response by modulating the immune response, preventing excessive inflammation and promoting immune homeostasis.

Sounds pretty good so far, right?

The next question you most likely have is “where can I find these?”

PRMs are mostly found in omega-3 fat rich foods such as fatty fish, flaxseeds and chia seeds. Antioxidant rich foods, such as fruits, vegetables and nuts, are also beneficial to consume because they will support the production of PRMs. 

For the most part, it is easy to consume PRMs through food, however, you will likely not have a high rate of conversion from just eating omega-3 rich foods. As such, it may be helpful to consider taking a PRM supplement. More on PRM supplements in a future article but if you are considering a PRM supplement, contact the eNRG Performance Sport Dietitian team and we can help you.